DNA methylation stochasticity is linked to transcriptional variability and identifies convergent epigenetic disruption across genetically-defined subtypes of AML [scRNAseq]
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ABSTRACT: Epigenetic regulators are frequently mutated in acute myeloid leukemia (AML). We applied the CPEL method to publicly-available ERRBS data to investigate DNA methylation stochasticity in genetic subtypes of AML, and identified transcriptional dysregulation related to methylation entropy using single-cell RNA-seq data.
ORGANISM(S): Homo sapiens
PROVIDER: GSE281087 | GEO | 2026/03/09
REPOSITORIES: GEO
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