Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

FSTL1 Promotes Macrophage M2 Polarization and Its Role in Allergic Rhinitis

ABSTRACT: Allergic rhinitis (AR) is a prevalent inflammatory condition characterized by an overactive immune response to allergens. Recent studies have highlighted the role of macrophage polarization in modulating immune responses. This study investigates the role of Follistatin-like 1 (FSTL1) in promoting macrophage M2 polarization and its implications in AR. Using in vitro and in vivo models, we demonstrate that FSTL1 significantly enhances the expression of M2 macrophage markers, including Arg1, CD206, and IL-10, while concurrently reducing M1 markers such as iNOS and TNF-α. Furthermore, FSTL1-treated macrophages exhibited increased anti-inflammatory properties, contributing to the attenuation of allergic inflammation in a murine model of AR. Our findings suggest that FSTL1-mediated M2 polarization plays a crucial role in mitigating allergic responses, providing a potential therapeutic target for AR management.

ORGANISM(S): Homo sapiens

PROVIDER: GSE281116 | GEO | 2025/11/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

FSTL1 Promotes Macrophage M2 Polarization and Its Role in Allergic Rhinitis

Project description:FSTL1 Promotes Macrophage M2 Polarization and Its Role in Allergic Rhinitis

| PRJNA1182316 | ENA

Project description:Allergen exposure was thought to play a critical role in the etiology of AR. And allergen avoidance, the practice of avoiding exposure to allergens, has been generally advised as the management of AR. However, the effect is uncertain and the underlying mechanism is far from known. We used gene expression microarrays to identify genes differentially regulated by allergen avoidance in allergic rhinitis mouse model.

2013-11-28 | GSE52804 | GEO

control versus allergic rhinitis basal cells in response to Der p1

Project description:Basal cells are the epithelial progenitor cells of the airways and play a critical role in tissue homeostasis and repair. In a healthy upper airway epithelium, the basal cells are usually shielded from environmental triggers as they are positioned in close contact with the basement membrane. In allergic rhinitis, it is known that the epithelial barrier is dysfunctional and it is believed that in this situation basal cells become more accessible to airborne particles, however, it is not known whether basal cells can sense these triggers directly. In addition, previous research has shown that control basal cells phenotypically and functionally differ from allergic rhinitis (AR) basal cells. In this study, we aimed to further compare phenotypical differences between sorted primary control and house dust mite (HDM)-allergic AR basal cells, before and after culture, using bulk RNA sequencing. Moreover, we wanted to evaluate the basal cell transcriptional response to HDM-derived Der p1 to study their potential as an environmental sensor.

2025-04-01 | GSE288682 | GEO

Therapy of allergic rhinitis using ribavirin spray to clear nasal commensal viruses

Project description:For analyzing the exploratory nasal commensal viruses, we performed the metatranscriptomic analysis of the nose swabs from the enrolled AR patients both before and after treatments, as well as sequenced the nose swabs from a set of healthy volunteers without AR history.Simultaneously, to assess the expression of interferon-stimulated genes in patients with allergic rhinitis, we analyzed the gene expression of host reads.

2024-08-21 | GSE275114 | GEO

Expression data from airway epithelial cells from patients with asthma, rhinitis, and helathy controls

Project description:The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these disorders can be captured by gene expression profiling we hypothesized that the clinical expression of rhinitis and/or asthma is related to differential gene expression between upper and lower airways epithelium. We used micro array to profile gene expression of primary nasal and bronchial epithelial cells from the same individuals and examining the impact of allergic rhinitis with and without concomitant allergic asthma on expression profiles. 17 subjects were included in a cross-sectional study (6 allergic asthma and allergic rhinitis; 5 allergic rhinitis; 6 healthy controls). RNA was extracted from isolated and cultured epithelial cells from bronchial brushes and nasal biopsies, and analyzed by microarray (Affymetrix U133+ PM Genechip Array).

2013-02-05 | E-GEOD-44037 | biostudies-arrayexpress

Homo Sapiens Nasal Inferior Turbinates of house dust mite-induced allergic rhinitis and controls

Project description:To elucidate the epithelial cell diversity within the nasal inferior turbinates, a comprehensive investigation was conducted comparing control subjects to individuals with house dust mite-induced allergic rhinitis. This study aimed to delineate the differential expression profiles and phenotypic variations of epithelial cells in response to allergic rhinitis. This research elucidated distinct subpopulations and rare cell types of epithelial cells within the nasal turbinates, discerning alterations induced by allergic rhinitis. Furthermore, by interrogating transcriptomic signatures, the investigation provided novel insights into the cellular dynamics and immune responses underlying allergic rhinitis pathogenesis

2024-05-30 | GSE261706 | GEO

Global gene expression of nasal epithelial cells in patients with seasonal allergic rhinitis

Project description:Analysis of nasal epithelial cells from adult patients with seasonal allergic rhinitis and from non allergic controls. Results provide insight into the molecular mechanisms associated with inflammatory responses in nasal mucosa. Total RNA was obtained from nasal epithelial cells of 7 seasonal allergic rhinitis patients and 5 non-allergic control subjects

2015-01-16 | E-GEOD-43523 | biostudies-arrayexpress

Single-cell RNA Sequencing Reveals Immune Cell Alterations in Patients with Allergic Rhinitis Treated with Peiyuan Tongqiao Decoction

Project description:Allergic rhinitis (AR), a chronic inflammatory disorder with complex causative mechanisms, threat to human physical and mental health. Traditional Chinese medicine (TCM) are gaining attention due to their potential ability to treat AR. The aim of this study was to elucidate biological activity of Peiyuan Tongqiao Decoction that can act on the different processes of AR through cell abundance, DEGs, pathways and transcription factors (TFs) through single-cell RNA sequencing (scRNA-seq)

2025-08-05 | GSE273975 | GEO

Altered expression of long noncoding RNAs regulating neutrophilic inflammation in peripheral blood was associated with symptom severity in patients with house dust mite-induced allergic rhinitis

Project description:Long noncoding RNAs (lncRNAs) have been implicated in a diverse array of human immune diseases; however, a comprehensive understanding of the expression and function of lncRNAs in the peripheral blood leukocytes of individuals suffering from house dust mite (HDM)-induced allergic rhinitis (AR) remains elusive.

2025-08-31 | GSE274277 | GEO

Expression data from airway epithelial cells from patients with asthma, rhinitis, and helathy controls

2013-02-05 | GSE44037 | GEO