Transcriptomic profiling of signet ring cell precursors of diffuse-type gastric cancer informs latent phenotype

ABSTRACT: Germline CDH1 loss-of-function mutations are causally linked to an increased lifetime risk of diffuse gastric cancer (DGC). Early, multifocal signet ring cell (SRC) lesions are ubiquitous among CDH1 variant carriers, yet only a subset of patients will develop advanced DGC. Transcriptomic profiling was performed to establish the molecular phenotype of early SRC lesions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE281274 | GEO | 2025/02/21

REPOSITORIES: GEO