Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profile at the single cell level of tumor endothelial cells from two orthotopic mouse models: KPC (pancreas) and PYMT (breast).

ABSTRACT: Single cell analyses have revealed unexpected diversity of endothelial cell subsets in various tissues. However, the expression provile and divsersity of EC in tumor tissue has remained less clear.

ORGANISM(S): Mus musculus

PROVIDER: GSE281284 | GEO | 2025/06/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression profile at the single cell level of tumor endothelial cells from two orthotopic mouse models: KPC (pancreas) and PYMT (breast).

Project description:Gene expression profile at the single cell level of tumor endothelial cells from two orthotopic mouse models: KPC (pancreas) and PYMT (breast).

| PRJNA1183311 | ENA

A multiplexing strategy to create primary and orthotopic endometrial cancer models in mice

Project description:Endometrial cancer (EC) is the most common female reproductive tract cancer and its incidence is continuously rising recently. The underlying mechanisms of EC tumorigenesis remain unclear and efficient target therapies are lack, both of which require feasible endometrial cancer animal models for translational studies. Here, we report an organoid and genome editing-based strategy to generate primary, orthotopic, and drivers-defined ECs in mice. Bulk RNA sequencing was performed with organoids of various genetics-mediated EC models.

2023-05-16 | GSE203121 | GEO

antigenic KPC model_bulk pancreas RNASeq

Project description:We report the application of bulk RNAseq of live cells from pancreas of KPC or KPC-OG genetic mice at 6 weeks of age. These sponteneous tumors were unperturbed otherwise until timepoint.

2020-01-01 | GSE131602 | GEO

antigenic KPC model_bulk pancreas RNASeq

Project description:antigenic KPC model_bulk pancreas RNASeq

| PRJNA544120 | ENA

Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development.

Project description: Not available

| S-EPMC365721 | biostudies-literature

Immunophenotyping of Orthotopic Homograft (Syngeneic) of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry.

Project description: Not available

| S-EPMC6235480 | biostudies-literature

Murine models of pancreatic cancer: KPC

Project description:We harvested and sequenced the spontaneous pancreatic tumor generated by a 6-month-old KPC mouse (KrasLSL-G12D; Trp53LSL-R172H; Ptf1a-Cre).

2022-10-04 | GSE202651 | GEO

Two-Level Dynamic Structural Equation Models with Small Samples.

Project description: Not available

| S-EPMC7451754 | biostudies-literature

RNA-seq of Sting overexpressing orthotopic pancreas tumors

Project description:Murine pancreatic PKCY tumor cells (p53fl/+;KrasLSL-G12D/+;Pdx1-Cre;Rosa26LSL-YFP) were engineered to overexpress Sting or empty vector control. Tumor cells were orthotopically transplanted into the pancreas of syngeneic littermates. Tumors were harvested and RNA seq for transcriptomic differences was performed.

2021-09-06 | E-MTAB-10722 | biostudies-arrayexpress

Single-cell RNAseq of from murine pancreas tumor (KPC)

Project description:Pancreatic ductal adenocarcinoma (PDAC) co-opts the peripheral nervous system through nerve hypertrophy, axonogenesis and perineural invasion, and these processes correlate with patient morbidity and mortality. Prior work has shown that autonomic nerves directly modulate neoplastic cells in PDAC, but whether cancer-associated fibroblasts (CAFs) participate in neural remodeling is unknown. Using thick tissue sections, we identified dense neo-innervation near myofibroblastic CAFs (myCAFs) in preinvasive Pancreatic Intraepithelial Neoplasms (PanINs). Mechanistically, TGF-β produced during inflammation and neoplasia triggers myofibroblast formation, and myCAFs produce axon guidance molecules that recruit sympathetic nerves. Norepinephrine released by sympathetic nerves activates myofibroblast cultures in vitro, and sympathetic nerve depletion impairs stromal activation and PDAC growth in vivo. A chemogenetic model confirmed that fibroblast-specific α1-adrenergic signaling exacerbated pancreatic inflammation and neoplasia. Therefore, beyond direct epithelial effects, sympathetic nerves promote pancreatitis and PDAC by co-opting myofibroblasts and myCAFs as disease amplifiers, highlighting CAF subtype-specific stromal interactions as putative therapeutic targets.

2026-01-09 | GSE294749 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data