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In situ single-cell profiling of a brain metastasis from a HER2+ Breast Cancer Patient and 8 primary tumors from TNBC patients.

ABSTRACT: A key problem in cancer biology is understanding the phenotypic characteristics of the aggressive cell states present in macrometastases and their molecular underpinnings. Here we report on the cellular constituents of breast cancer metastases, revealing that these malignant cells display a gene-expression profile associated to embryonic development of tubular organs. Similar properties are found in malignant cells from pro-metastatic primary tumors but not in primary tumors that never metastatize.

ORGANISM(S): Homo sapiens

PROVIDER: GSE281488 | GEO | 2026/03/27

REPOSITORIES: GEO

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