Inflammation switches the chemoattractant requirements for naïve lymphocyte entry into lymph nodes

ABSTRACT: CCL21 is downregulated in stroma during inflammation of the lymph node. The factors controlling this repression are unknown. ATAC-seq was performed on naïve and inflamed lymph node fibroblasts to elucidate the signals controlling CCL21 downregulation and other lymph node stromal inflammatory programs.

ORGANISM(S): Mus musculus

PROVIDER: GSE281684 | GEO | 2024/11/13

REPOSITORIES: GEO