Gene expression analysis of different motor neuron genotypes and their response to biological exposure and AAV treatment

ABSTRACT: Wild-type motor neurons and motor neurons carrying ALS-relevant mutations (TDP-43 - M337V; SOD1 - G93A) were cultured and exposed different biological treatments in the absence and presence of AAV(s) (1-5) transduction and consequent protein expression. Their response to these variables under different combinations was assessed with regards to gene expression using nCounter Gene Expression Panels (nanoString), Neuropathology and Neuroinflammation Panels.

ORGANISM(S): Homo sapiens

PROVIDER: GSE281698 | GEO | 2024/12/01

REPOSITORIES: GEO