Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GRHL2 derepression triggers pathophysiological hepatocyte to cholangiocyte trans-differentiation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE281717 | GEO | 2025/12/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

GRHL2 derepression triggers pathophysiological hepatocyte to cholangiocyte transdifferentiation

Project description:HepG2 cells were used for GRHL2 ChIP-seq

2025-12-30 | GSE281378 | GEO

GRHL2 derepression triggers pathophysiological hepatocyte to cholangiocyte trans-differentiation

Project description:GRHL2 derepression triggers pathophysiological hepatocyte to cholangiocyte trans-differentiation

| PRJNA1185272 | ENA

GRHL2 derepression triggers pathophysiological hepatocyte to cholangiocyte transdifferentiation [RNAseq_HepG2_EZHi]

Project description:Transcriptome of human HepG2 cells treated or not with Ezh1/2 inhibitors (UNC1999 and Valmetostat Tosylate).

2025-12-30 | GSE281712 | GEO

GRHL2 derepression triggers pathophysiological hepatocyte to cholangiocyte transdifferentiation

Project description:GRHL2 derepression triggers pathophysiological hepatocyte to cholangiocyte transdifferentiation

| PRJNA1183757 | ENA

GRHL2 derepression triggers pathophysiological hepatocyte to cholangiocyte transdifferentiation [RNAseq_HepG2_EZHi]

Project description:GRHL2 derepression triggers pathophysiological hepatocyte to cholangiocyte transdifferentiation [RNAseq_HepG2_EZHi]

| PRJNA1185274 | ENA

Derepression of the DNA Methylation Machinery of the Gata1 Gene Triggers the Differentiation Cue for Erythropoiesis.

Project description:GATA1 is a critical regulator of erythropoiesis. While the mechanisms underlying the high-level expression of GATA1 in maturing erythroid cells have been studied extensively, the initial activation of the Gata1 gene in early hematopoietic progenitors remains to be elucidated. We previously identified a hematopoietic stem and progenitor cell (HSPC)-specific silencer element (the Gata1 methylation-determining region [G1MDR]) that recruits DNA methyltransferase 1 (Dnmt1) and provokes methylation of the Gata1 gene enhancer. In the present study, we hypothesized that removal of the G1MDR-mediated silencing machinery is the molecular basis of the initial activation of the Gata1 gene and erythropoiesis. To address this hypothesis, we generated transgenic mouse lines harboring a Gata1 bacterial artificial chromosome in which the G1MDR was deleted. The mice exhibited abundant GATA1 expression in HSPCs, in a GATA2-dependent manner. The ectopic GATA1 expression repressed Gata2 transcription and induced erythropoiesis and apoptosis of HSPCs. Furthermore, genetic deletion of Dnmt1 in HSPCs activated Gata1 expression and depleted HSPCs, thus recapitulating the HSC phenotype associated with GATA1 gain of function. These results demonstrate that the G1MDR holds the key to HSPC maintenance and suggest that release from this suppressive mechanism is a fundamental requirement for subsequent initiation of erythroid differentiation.

| S-EPMC5376630 | biostudies-literature

LSD1 inhibition promotes epithelial differentiation through derepression of fate- determining transcription factors

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-08-20 | GSE133766 | GEO

Primary human bronchial epithelial cells expressing EGFP or DN-GRHL2

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-05-08 | E-GEOD-44809 | biostudies-arrayexpress

Frequent and Transient Acquisition of Pluripotency During Somatic Cell Trans-Differentiation with iPSCs Reprogramming Factors

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-04-30 | E-GEOD-67299 | biostudies-arrayexpress

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

Project description:This SuperSeries is composed of the SubSeries listed below.