Transcriptomics

Dataset Information

0

MRNA profiles of Celf1fl/fl and adipocyte-specific Celf1 deficiency (Celf1fl/fl AKO) in iWAT after acute cold stimulation


ABSTRACT: RNA-seq reveals the critical role of adipocyte Celf1 in cold-responsive thermogenic remodeling in inguinal white adipose tissue (iWAT). The cold-induced thermogenic program in iWAT was severely blunted in Celf1AKO mice, especially the obvious downregulation of Ucp1, Dio2, Elvol3, Tbx1, Cox7a1, and Cidea genes. The GO analysis revealed that the down-regulated genes were primarily involved in adaptive thermogenesis, temperature homeostasis, and mitochondrial-related processes, including lipid oxidation, fatty acid metabolism and so on. KEGG pathway analysis further showed that these down-regulated genes were involved in thermogenesis-related pathways, including thermogenesis, PPAR signaling, metabolic pathways, fatty acid degradation, and AMPK signaling. Together, these results suggest that adipocyte Celf1 deficiency impairs cold-induced iWAT thermogenic program.

ORGANISM(S): Mus musculus

PROVIDER: GSE281771 | GEO | 2025/07/05

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-08-18 | GSE154047 | GEO
2025-07-05 | GSE297248 | GEO
2022-07-21 | GSE180524 | GEO
2021-12-14 | GSE133619 | GEO
2024-01-10 | PXD047841 | Pride
2022-02-26 | GSE185067 | GEO
2022-05-11 | GSE179385 | GEO
2021-10-28 | E-MTAB-8966 | biostudies-arrayexpress
2022-02-06 | E-MTAB-8965 | biostudies-arrayexpress
2018-02-14 | GSE85335 | GEO