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Gene expression profiles of Col1α1+Vldlr+ and Col1α1+Vldlr- TSPCs

ABSTRACT: We here report Reln-VLDLR receptor-ligand interactions are the primary mechanism for communication between lymphatic endothelial cells (LECs) and tendon stem/progenitor cells (TSPCs). The depletion of Vldlr results in impaired tendon regeneration.Specifically, lymphoangiocrine Reelin interacts with Col1α1+Vldlr+TSPCs to activate Notch1-Srebf2 mediated cholesterol metabolism loop, maintaining TSPC stemness and enhancing tendon regeneration.

ORGANISM(S): Mus musculus

PROVIDER: GSE282034 | GEO | 2025/11/11

REPOSITORIES: GEO

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gene expression profiles of Col1α1+Vldlr+ and Col1α1+Vldlr- TSPCs

Project description:gene expression profiles of Col1α1+Vldlr+ and Col1α1+Vldlr- TSPCs

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