CRISPR screening reveals that RNA helicase DDX41 triggers ribosome biogenesis and cancer progression through R-loop-mediated RPL/RPS transcription

ABSTRACT: Our findings showed that high-expressed DDX41 translocates to the R-loop structure of RPL/RPS genes, accelerating their transcription and promoting ribosome biogenesis. Additionally, acetyltransferase KAT8 is required for H3K9ac modification of the DDX41 promoter, while NR2C1/NR2C2 are responsible for regulating DDX41 transcription.

ORGANISM(S): Homo sapiens

PROVIDER: GSE282326 | GEO | 2025/07/01

REPOSITORIES: GEO