Transcriptomic analysis of severe allergic patch test reactions to different allergens (nickel, 2-hydroxyethylmethacrylate, methylisothiazolinone and formaldehyde)

ABSTRACT: Background: Immune mechanisms underlying elicitation in allergic contact dermatitis (ACD) are not disclosed. Previous studies have shown a double-faceted nature of ACD with both common biomarkers between different allergens, as well as allergen-specific imprinting, with discordance in terms of relevant involved immune pathways. Objectives: To characterize molecular signatures and their immune mechanisms between different relevant allergens (nickel, 2-hydroxyethylmethacrylate (2-HEMA), methylisothiazolinone (MI), formaldehyde) in strong and extreme patch test reactions of patients without atopic dermatitis using RNA sequencing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE282562 | GEO | 2025/07/16

REPOSITORIES: GEO