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SH2D1A Promotes CHI3L2 Expression and Facilitates the Progression of T-Cell Acute Lymphoblastic Leukemia

ABSTRACT: T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy. The potential of investigating SH2D1A holds promise for more targeted therapies and better outcomes. Knocking down SH2D1A led to decreased T-ALL cell survival and growth both in vitro and in vivo. RNA-seq analysis was conducted and the differently expressed genes were revealed in the SH2D1A-knockdown Jurkat and 6T-CEM cells in comparison to control group.

ORGANISM(S): Homo sapiens

PROVIDER: GSE283165 | GEO | 2025/04/21

REPOSITORIES: GEO

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