Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Canine morbillivirus infection of primary alveolar macrophages provides insights into mechanisms of viral interference with innate immune defense responses

ABSTRACT: Morbillivirus canis (formerly: canine distemper virus, CDV) is a highly contagious pathogen with a broad host range among carnivore species. During respiratory infection, alveolar macrophages (AMs) are among the first cell types facing the virus, which has previously been shown for measles virus infection. While AMs contribute to pulmonary homeostasis, they likewise bear great potential in establishing a pro-inflammatory environment once confronted with viruses. This study aimed to investigate cellular defense responses by AMs, allowing assumptions on early pathogenesis of CDV.

ORGANISM(S): Canis lupus familiaris

PROVIDER: GSE283373 | GEO | 2025/12/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Measles morbillivirus

Project description:CNS Measles morbillivirus

| PRJNA594952 | ENA

Systematic Analysis of Lysine Succinylation in Vero cell infected with small ruminant morbillivirus

Project description:Small ruminant morbillivirus (SRMV), formerly named Peste-des-petits ruminanats virus (PPRV), belongs to the genus Morbillivirus genus in the family Paramyxoviridae and leads to a highly contagious disease in small ruminants, especially goats and sheep. Lysine succinylation is a newly identified and conserved modification and plays important roles in host cells response to pathogen infection. Herein, we present the comprehensive analysis of the succinylome of SRMV-infected Vero cell using quantitative proteomics. Overall, we identified 875 succinylated proteins with 2840 succinylation sites. Comparative analysis revealed that 139 down-regulated succinylated proteins with 228 succinylation sites and 38 up-regulated succinylated proteins with 44 succinylation sites were significant succinylated in response to SRMV infection, seven lysine succinylation motifs were identified. Bioinformatics analysis showed that the succinalated proteins mainly participated in in cellular respiration and biosynthetic process. Protein-protein interaction networks of the identified proteins provided further evidence that a variety of ATP synthase subunits and carbon metabolism were modulated by succinylation, the overlapped proteins between succinylation and acetylation are involved in glyoxylate and dicarboxylate metabolism. In summary, this is the first study of the succinylome in SRMV infection, lysine acetylation may have a more important eﬀect than succinylation in PPRV infection. It provides a novel view on investigating the infection mechanism of SRMV.

2025-05-06 | PXD025025 | Pride

Transcriptomic analysis reveals the multifaceted impairments of DC functions produced by a Morbillivirus infection

Project description:Viruses have evolved numerous strategies to impair immunity so that they can replicate more efficiently, such as the immunosuppressive effects of Morbillivirus infection. In the present work we hypothesized that the highly contagious morbillivirus Peste des Petits Ruminants virus (PPRV) could target monocytes and dendritic cells (DC) to contribute to the immunosuppressive effects produced by the infection. Monocytes isolated from healthy sheep donor, a natural host of the disease, could be infected by PPRV and this impaired the differentiation and phagocytic ability of immature monocyte-derived DC (MoDC). Ovine MoDC could be productively infected by PPRV, and this drastically reduced MoDC capacity to activate allogeneic T cell responses. Transcriptomic analysis of infected MoDC indicated that several tolerogenic DC signature genes were upregulated upon PPRV infection.

2022-09-06 | GSE203515 | GEO

Measles morbillivirus

Project description:Measles morbillivirus Genome sequencing

| PRJNA750463 | ENA

Measles morbillivirus

Project description:Measles morbillivirus Genome sequencing and assembly

| PRJNA1241325 | ENA

Measles morbillivirus strain:D8

Project description:Measles morbillivirus strain:D8 Genome sequencing

| PRJNA480551 | ENA

Morbillivirus canis

Project description:Morbillivirus canis Raw sequence reads