NNMT promotes tubular senescence and fibrosis in chronic kidney disease (db/m and db/db mice kidney)

ABSTRACT: Diabetic kidney disease is the leading cause of chronic kidney disease. db/db mice, which carry a deletion mutation resulting in a dysfunctional leptin receptor, exhibit hyperphagia, obesity, and elevated insulin levels, making them a widely used preclinical model of diabetic kidney disease. At 16 weeks of age, db/db mice showed enriched transcriptomic signatures of cellular senescence in their kidneys compared to control db/m mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE283610 | GEO | 2025/11/20

REPOSITORIES: GEO