Transcriptomics

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Modeling aspects of human early post-implantation development with stem cells


ABSTRACT: Early post-implantation development in humans, often a 'black box' due to limited access to natural embryos, has recently been studied using integrated stem cell-based embryo models (SCBEMs) that include most, if not all, embryonic and extraembryonic cell types. However, these models face challenges in reproducibility, efficiency, genomic and epigenomic stability, and/or fidelity, necessitating further development and refinement. Here, we have optimized a method for generating SCBEMs by combining primed human pluripotent stem cells (hPSCs) with transgene-induced extraembryonic cells from naïve hPSCs. The resulting inducible SCBEMs (iSCBEMs) effectively mimic key features of early post-implantation human concepti, including the development of amniontic, yolk sac and chorionic cavities, differentiation of syncytiotrophoblast-like cells forming lacunae, bilaminar disk formation, the establishment of the A-P axis and early stages of gastrulation. Human iSCBEMs offer a valuable alternative for studying early human post-implantation development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE283908 | GEO | 2025/08/20

REPOSITORIES: GEO

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