Genomics

Dataset Information

0

Expression data from mouse embryo fibroblast (MEFS)


ABSTRACT: The role of p53 in assuring longevity through prevention of cancer is well established, but how it specifically regulates aging is still controversial. Our assumption is that distinct p53-pathways regulate tumor suppression and aging and that p66Shc is one of the master regulators of the p53 aging function. p66Shc longevity determinant protein acts as a downstream target of p53 and it is indispensable for the ability of activated p53 to induce elevation of intracellular oxidants and apoptosis. We used microarray to gain insight into the mechanism through which p66Shc could regulate p53 oxidative stress dependent activity.

ORGANISM(S): Mus musculus

PROVIDER: GSE28416 | GEO | 2012/04/02

SECONDARY ACCESSION(S): PRJNA143247

REPOSITORIES: GEO

Similar Datasets

2012-04-01 | E-GEOD-28416 | biostudies-arrayexpress
2012-04-01 | E-GEOD-28417 | biostudies-arrayexpress
2012-04-02 | GSE28417 | GEO
2022-12-21 | GSE201253 | GEO
2008-12-30 | E-GEOD-11244 | biostudies-arrayexpress
2024-01-29 | GSE224075 | GEO
2024-01-29 | GSE224076 | GEO
2023-10-04 | GSE244493 | GEO
2022-05-06 | MTBLS4654 | MetaboLights
2008-12-31 | GSE11244 | GEO