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RNA sequencing on liver samples from wild type C57BL/6J mice exposed to the vandetanib

ABSTRACT: Purpose: The aim of this study was to demonstrate the hepatotoxicity mechanism induced by vandetanib. Methods: Liver mRNA profiles of C57BL/6J mice exposed to the vandetanib were generated by RNA sequencing. Results: We analyzed the results of high-throughput transcriptome sequencing on liver samples from C57BL/6J mice exposed to the vandetanib and identified that vandetanib increased apoptosis-related genes expression apoptosis and the JAK-STAT signaling pathway was significantly enriched.

ORGANISM(S): Mus musculus

PROVIDER: GSE284661 | GEO | 2025/12/18

REPOSITORIES: GEO

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