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The energy-saving metabolic switch underlies survival of extremophilic red microalgae in extremely high nickel levels

ABSTRACT: The red microalga Cyanidioschyzon merolae inhabits extreme environments of high temperature, high acidity, and the presence of high concentrations of heavy metals and sulphites that are lethal to most other forms of life. However, information is scarce on the precise adaptation mechanisms of this extremophile to such hostile conditions. Gaining such information is important for understanding the evolution of microorganisms in the early stages of life on Earth because these extreme environments are similar. By analyzing the remodeling of the global transcriptome upon long-term exposure of C. merolae to extremely high concentrations of nickel, the key adaptive metabolic pathways and associated molecular components were identified. Our work shows that long-term Ni exposure of C. merolae cells leads to the lagged metabolic switch demonstrated by transcriptional upregulation of the metabolic pathways critical for cell survival such as DNA replication, cell cycle, and protein quality control with the concomitant downregulation of energetically costly processes including assembly of the photosynthetic apparatus and lipid biosynthesis. This study paves the way for the multi-omic studies of the molecular mechanisms of abiotic stress adaptation in phototrophs, as well as the development of the rational approaches for bioremediation of contaminated aquatic environments by modifying expression of the critical molecular components identified here.

ORGANISM(S): Cyanidioschyzon merolae

PROVIDER: GSE284716 | GEO | 2025/05/14

REPOSITORIES: GEO

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