Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Compromised Intestinal Barrier Resilience to Disruption in People with HIV

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE284762 | GEO | 2025/12/17

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Compromised Intestinal Barrier Resilience to Disruption in People with HIV [colon]

Project description:People living with HIV (PLWH) experience chronic intestinal barrier dysfunction (gut leakage), which persists despite viral suppression by antiretroviral therapy (ART) and contributes to chronic inflammation and its comorbidities. The mechanisms underlying this phenomenon remain unclear and are likely multifactorial. We hypothesize that living with HIV compromises the intestinal barrier’s resilience to injurious agents, increasing susceptibility to leakage upon exposure to common exogenous or endogenous disruptors, such as alcohol or pro-inflammatory cytokines, respectively. Using 3D intestinal organoids (colonoids and enteroids) derived from PLWH on ART and HIV-negative controls, we assessed the impact of alcohol and inflammatory cytokines on barrier integrity. Organoids from PLWH exhibited reduced resilience to disruption compared to controls, correlating with alterations in pathways critical to epithelial integrity, including epithelial-mesenchymal transition, DNA repair, and oxidative stress-related pathways. These findings reveal a novel mechanism underlying intestinal dysfunction in PLWH and highlight potential molecular targets to mitigate these complications.

2025-12-17 | GSE284755 | GEO

Compromised Intestinal Barrier Resilience to Disruption in People with HIV [ileum]

2025-12-17 | GSE284761 | GEO

Compromised Intestinal Barrier Resilience to Disruption in People with HIV

Project description:Compromised Intestinal Barrier Resilience to Disruption in People with HIV

| PRJNA1200607 | ENA

Compromised Intestinal Barrier Resilience to Disruption in People with HIV [colon]

Project description:Compromised Intestinal Barrier Resilience to Disruption in People with HIV [colon]

| PRJNA1200605 | ENA

Compromised Intestinal Barrier Resilience to Disruption in People with HIV [ileum]

Project description:Compromised Intestinal Barrier Resilience to Disruption in People with HIV [ileum]

| PRJNA1200619 | ENA

The latent HIV reservoir in the brain of people with HIV under antiretroviral therapy

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-02-01 | GSE221688 | GEO

b-Catenin Mediates the Development of Behavioral Resilience

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-11-13 | E-GEOD-61296 | biostudies-arrayexpress

Endothelial sensing of AHR ligands regulates intestinal barrier immunity

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-07-12 | GSE201789 | GEO

BBBomics - Human Blood Brain Barrier Transcriptomics Hub

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-03-17 | E-GEOD-76531 | biostudies-arrayexpress

Variation in primary CD4+ T cell response to activation across time and people

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-08-28 | E-GEOD-60236 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data