Transcriptomics

Dataset Information

41

Effects of 20 months Dietary Methionine Restriction on Hepatic Gene Expression in Fischer 344 Rats


ABSTRACT: Dietary methionine restriction (MR) has been shown to increase lifespan and decrease adiposity in rodents. This study was designed to examine the transcriptional effects of MR in metabolically relevant tissues. This experiment contains data from the liver. Overall design: We analyzed MR-induced changes in gene expression using pooled RNA from liver of rats fed either a control purified amino acid diet (DL-methionine content of 0.86%) (CON) or a methionine-restricted diet (DL-methionine content of 0.172%)(MR). Rats were fed Purina rodent diet 5001 until 32 days of age and were then randomly assigned to be fed CON diet or MR diet for 20 months.

INSTRUMENT(S): ABI Rat Genome Survey Microarray

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Kirsten P Stone  

PROVIDER: GSE28482 | GEO | 2012-04-08

SECONDARY ACCESSION(S): PRJNA139311

REPOSITORIES: GEO

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