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CB1 receptor inhibition restores synaptoneurosomal alternative splicing landscape in fragile X syndrome mice

ABSTRACT: Using RNA sequencing, we analyzed synaptoneurosomal transcriptomic landscape of Fmr1 KO mice and wild type littermates and the modifications after sub-chronic (7 d) treatment with rimonabant at a dose of 0.1 mg/kg. We found that rimonabant had a limited impact at gene expression level in both Fmr1 KO and wild type mice compared to vehicle trated mice. Instead, rimonabant significantly modified transcript expression in Fmr1 KO mice compared to vehicle treated Fmr1 KO. Moreover, when analyzing alternative splicing events, many of the events modified in Fmr1 KO mice treated with vehicle were modulated by rimonabant to become similar to those found wild type mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE285032 | GEO | 2026/09/17

REPOSITORIES: GEO

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A serotonergic mechanism is involved in the procognitive effect of CB1R peripheral inhibition in a mouse model of fragile X syndrome

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