RNA-seq analysis of Calreticulin(Calr) knockout LLC cells identified ER stress response

ABSTRACT: To investigate the mechanisms by which Calreticulin inactivation increases tumor sensitivity to T cell-mediated anti-tumor immunity, LLC cells were transduced with sgRNA targeting Calreticulin or a control sgRNA, and transcriptome changes were profiled using paired-end RNA-seq. Our data demonstrated that Calr KO induces an ER stress response.

ORGANISM(S): Mus musculus

PROVIDER: GSE285113 | GEO | 2025/07/24

REPOSITORIES: GEO