Effect of pancreatic cancer derived extracellular vesicles on bone marrow drived macrophages

ABSTRACT: Our results show that PaCa cell derived EVs were taken up by the macrophage in a time-dependent manner that resulted in an immunosuppressive phenotype characterized by higher expression of CD206 and PD-L1 and higher secretion of immunosuppressive cytokines including TGF-beta, IL-10 and GM-CSF.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE285193 | GEO | 2025/12/22

REPOSITORIES: GEO