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Spatially resolved atlas of IPF fibroblastic foci identifies that PAK2 kinase activation is involved in fibrogenesis

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive fibrosis of the lung parenchyma. To identify potential therapeutic targets for IPF, we conducted spatial transcriptomic analysis and single-cell RNA sequencing (scRNA-seq). Our findings reveal that PAK plays a critical role in the immature fibroblast niche during fibrogenesis, highlighting its potential as a therapeutic target for the treatment of IPF.

ORGANISM(S): Homo sapiens

PROVIDER: GSE285246 | GEO | 2025/08/11

REPOSITORIES: GEO

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Spatially resolved atlas of IPF fibroblastic foci identifies that PAK2 kinase activation is involved in fibrogenesis

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