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Fos binding in hippocampal chromain 1 h after peritoneal KA administration

ABSTRACT: Fos induction is the most commonly used marker of neuronal activation. Here, we investigate the binding profile of Fos in the adult mouse hippocampus using antibodies specific against this transcription factor and the chromatin Immunoprecipitation coupled to DNA-sequencing (ChIP-seq) method. We generated profiles in basal conditions and 1 hour after neuronal stimulation. To trigger the syncronous activation of hippocampal exciatory neurons we treated the mice with kainic acid (KA) through peritoneal administration. This model of status epilepticus has been characterized in detail at the epigenomic level (Fernandez-Albert et al., 2019).

ORGANISM(S): Mus musculus

PROVIDER: GSE285372 | GEO | 2025/09/17

REPOSITORIES: GEO

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Fos binding in hippocampal chromain 1 h after peritoneal KA administration

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