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Intracellular Interleukin-1α in Peritumoral Monocytes Induces IL8 Production and Inhibits Mitophagy to Promote Stemness and Metastasis of Hepatocellular Carcinoma

ABSTRACT: In the current study, we found that IL-1α levels were significantly upregulated in peritumoral monocytes compared to nontumor and intratumor counterparts, and glycolytic switch mediated the upregulation of IL-1α via NF-κB signaling. The upregulated IL-1α was neither secreted by nor displayed on cell surface of monocytes. Rather, IL-1α translocated into nuclei to induce the production of IL-8, which effectively enhanced cancer cell stemness and tumor metastasis. Substantial amounts of IL-1α bound to mitochondria to inhibit mitophagy, inducing CA12 expression and macrophages accumulation via ROS-HIF-1α pathway. In accordance, IL-1α levels in peritumoral monocytes were positively correlated with both survival and tumor metastasis of HCC patients. Targeting IL-1α+ monocytes or IL-8 could effectively inhibited tumor progression and enhanced tumor responsiveness to immune checkpoint blockade therapy in mice in vivo. Our results revealed an intracellular regulatory role of IL-1α in modifying the pro-tumor functions of monocytes within specific tumor microenvironments, and pointed to both IL-1α and its downstream IL-8 as potential diagnostic and therapeutic targets for human HCC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE285415 | GEO | 2025/08/01

REPOSITORIES: GEO

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Intracellular Interleukin-1α in Peritumoral Monocytes Induces IL8 Production and Inhibits Mitophagy to Promote Stemness and Metastasis of Hepatocellular Carcinoma

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