Functional reprogramming of neutrophils within tumors by hypoxia-driven histone lactylation [scRNA-seq]

ABSTRACT: We used scRNAseq to study the mechanism underlying the functional reprogramming in brain tumors. scRNA-seq of FACS-sorted neutrophils was performed on mice with brain tumors (SB28). We showd that the immunosuppressive ability of brain-tumor infiltrating neutrophils was exclusively mediated by a population of highly glycolytic neutrophils expressing the transferrin receptor CD71.

ORGANISM(S): Mus musculus

PROVIDER: GSE285510 | GEO | 2025/02/14

REPOSITORIES: GEO