Transcriptomics

Dataset Information

0

The response of Melanoma cell line A375 to cytotoxic T lyphocyte killing after serum starvation and MKL1 overexpression


ABSTRACT: Changes in cellular state has dramatic impact on cancer cell responsiveness to cytotoxic T lyphocyte (CTL) killing. In this study we tested serum starvation and increasing cytoskeleton of cancer cells. Serum starvation significantly upregulated the expression of genes involved in cholesterol biogenesis, which might be due a dramatic reduction in cellular cholesterol level. Indeed, cholestrol reduction sensitized the human melanoma cell line A375 for CTL killing. However, increasing the cytoskeleton of cancer cells did not cause a change in cancer cell responsiveness to CTL killing, suggesting cholesterol-associated membrane composition other than cellular rigidity plays a more important role in determining cancer cell responsiveness to CTL killing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE285537 | GEO | 2025/05/22

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-07-19 | GSE245936 | GEO
| PRJNA1130989 | ENA
2012-11-01 | E-MTAB-1157 | biostudies-arrayexpress
2022-06-09 | PXD026948 | Pride
2022-06-09 | PXD021508 | Pride
2016-01-15 | E-GEOD-76889 | biostudies-arrayexpress
2020-07-31 | GSE149935 | GEO
2020-07-31 | GSE149934 | GEO
2020-07-31 | GSE149933 | GEO
2020-07-31 | GSE153397 | GEO