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Effect of Hypergravity on Transcriptomic and Electrophysiological Properties of Rat Ventricular Cardiomyocytes

ABSTRACT: This study investigates the impact of hypergravity (4g for 14 days) on the transcriptomic and electrophysiological profiles of rat ventricular cardiomyocytes. Using RNA sequencing, we identified significant changes in the expression of mechanically gated and mechanosensitive ion channel genes. Electrophysiological analyses revealed increased sensitivity of stretch-activated currents (ISAC) to mechanical stimuli in hypergravity-exposed cardiomyocytes. These findings highlight how altered gravitational conditions modulate cardiac cellular responses, with implications for understanding mechanoelectric feedback in both physiological and extreme environments.

ORGANISM(S): Rattus

PROVIDER: GSE285899 | GEO | 2025/07/05

REPOSITORIES: GEO

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