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Spatial transcriptomics reveals the immunomodulatory activities of an oncolytic adenovirus armed with a type I interferon in a replication-permissive immunocompetent pancreatic cancer model

ABSTRACT: Oncolytic adenoviruses (OAds) are emerging as a promising class of viro-immunotherapy. Here, we focused on a replication-competent OAd armed with a type I interferon (OAd-IFN) and assessed its immunological activities in a replication-permissive, immunocompetent Syrian hamster pancreatic cancer model. Our spatial transcriptomic analysis revealed the critical role of locally expressed type I IFN in the immunomodulatory activities of OAd-IFN in the tumor microenvironment.

ORGANISM(S): Mesocricetus auratus

PROVIDER: GSE286008 | GEO | 2025/01/14

REPOSITORIES: GEO

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