Transient dietary intervention induces healthy adipose tissue expansion and metabolically healthy obesity in mice

ABSTRACT: As obesity progresses, dynamic tissue remodeling of adipose tissue occurs over time, i.e., adipocyte hypertrophy, chronic inflammation, and interstitial fibrosis. Some obese individuals exhibit healthy adipose tissue expansion, characterized by modest inflammation and fibrosis despite adipocyte hypertrophy, resulting in “Metabolically Healthy Obesity (MHO)”. Our research has revealed that MHO can be induced by temporary weight loss during the development of obesity.

ORGANISM(S): Mus musculus

PROVIDER: GSE286420 | GEO | 2025/07/23

REPOSITORIES: GEO