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Gene expression profile at single cell level of genetically defined organoid models in neoplastic evolution of head and heck squamous cell carcinoma

ABSTRACT: To investigate the molecular mechanisms driving neoplastic evolution in head and neck squamous cell carcinoma, we established genetically defined mouse tongue organoid models harboring key driver mutations: control (Ctrl), Trp53/Cdkn2a dual-knockout with a control vector (DKOC), and Trp53/Cdkn2a dual-knockout with the PIK3CA E545K mutation (DKOP), and performed single-cell RNA sequencing (scRNA-seq) using the 10x Genomics platform on these organoid lines.

ORGANISM(S): Mus musculus

PROVIDER: GSE286449 | GEO | 2026/01/01

REPOSITORIES: GEO

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