Identification of p53-regulated microRNAs in Hapatocellular Carcinoma (HCC).
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ABSTRACT:
ORGANISM(S): Homo sapiens
PROVIDER: GSE28661 | GEO | 2011/05/11
SECONDARY ACCESSION(S): PRJNA138865
REPOSITORIES: GEO
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Project description:p53 suppresses tumor progression and metastasis by regulating a large set of genes and microRNAs. By profiling 92 primary hepatocellular carcinomas (HCCs) and 9 HCC cell lines, we found that p53 upregulates microRNAs including miR-200 and miR-192 family members. By sequencing TP53 in 92 HCC samples, we classified the 92 samples into two groups (wt and mut). We also classified 9 HCC cell lines by testing p21 expression after DNA-damage mediated p53 activation. We then profiled microRNA expression in 92 HCC tissue samples and 9 HCC celll lines to identify p53-regulated microRNAs.
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