Genomics

Dataset Information

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CUL4B and KDM5B ChIP-sequencing in MCF-7 cells


ABSTRACT: Estrogen receptor-positive (ER+) breast cancer is the predominant subtype of breast cancer. Here, we investigate the functional interplay between lysine demethylase 5B (KDM5B) and the Cullin-RING ligase 4B (CRL4B) complex in modulating cholesterol metabolism to promote ER+ breast cancer progression. We found that disrupting the KDM5B–CRL4B axis impairs cholesterol homeostasis and inhibits tumor growth.

ORGANISM(S): Homo sapiens

PROVIDER: GSE286885 | GEO | 2026/02/18

REPOSITORIES: GEO

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