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CDK10 suppresses nucleic acid sensors-mediated antitumor immunity [RNA-Seq]

ABSTRACT: Cdk10 knockout significantly reduced CT26 tumor growth in immunocompetent BALB/c WT mice.To elucidate the molecular mechanisms by which Cdk10 suppresses anti-tumor immunity, we conducted transcriptomic analyses on WT and Cdk10 KO CT26 cells

ORGANISM(S): Mus musculus

PROVIDER: GSE287054 | GEO | 2025/10/27

REPOSITORIES: GEO

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CDK10 suppresses nucleic acid sensors-mediated antitumor immunity [scRNA-Seq]

Project description:Cdk10 knockout significantly reduced CT26 tumor growth in immunocompetent BALB/c WT mice. To investigate how Cdk10 influences the tumor immune microenvironment in vivo, we performed single-cell RNA sequencing (scRNA-seq) on WT and Cdk10 KO CT26 tumors derived from immunocompetent BALB/c mice.

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