Junctophilin-2 regulation of gene expression in primary mouse cardiac fibroblasts.
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ABSTRACT: Calcium homeostasis in cardiac fibroblasts (CFs) are thought to play a critical role in myocardial repair and remodeling following injury. Junctophilin-2 (JP2) is a structural protein known to regulate intracellular calcium signaling and excitation-contraction coupling in cardiomyocytes. However, the role of JP2 in CF biology remains unexplored. To investigate the functional role of JP2 in CFs, we transduced primary CFs with adenoviruses expressing GFP, JP2, or a JP2 targetting shRNA and determined differentially expressed genes via RNA-sequencing. JP2 overepression and silencing had opposite effects on the expression of genes associated with fibrosis, migration, and cell division.
ORGANISM(S): Mus musculus
PROVIDER: GSE287096 | GEO | 2025/06/23
REPOSITORIES: GEO
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