Gene expression profiles of normal and tumor tissues from denervated prostate and intact prostate .

ABSTRACT: The phenotype and genotype of the tumors that arise in denervated prostates is not a measure of the effects of denervation on established tumors. Rather, it is a measure of their ability to escape the regulatory influence of the neural microenvironment and hence develop a resistance phenotype to denervation. This applies to human prostate cancer that arose in prostates with spinal cord injury. Our results indicate that tumors arising in denervated prostates have a significantly altered gene profile as compared to tumors arising in intact prostates.

ORGANISM(S): Homo sapiens

PROVIDER: GSE28718 | GEO | 2017/11/30

SECONDARY ACCESSION(S): PRJNA143065

REPOSITORIES: GEO