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Longitudinal Methylomic changes in PTSD following Sub-Anaesthetic Oral Ketamine Administration

ABSTRACT: This study is part of an investigation into the differential gene expression and methylation patterns in response to sub-anaesthetic oral ketamine treatment of PTSD to identify key molecular markers in building a predictive profile in determining longer term treatment outcomes. The data from this study is included in a number of articles and highlights the utility of combining gene expression data with epigenetic data and clinical outcomes to elucidate molecular profils receptive to ketamine’s sustained therapeutic effects as a step towards precision medicine.

ORGANISM(S): Homo sapiens

PROVIDER: GSE287261 | GEO | 2026/01/17

REPOSITORIES: GEO

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Longitudinal Gene Expression Changes in PTSD Following Sub-Anaesthetic Oral Ketamine Administration

Project description:This study investigates the differential gene expression in response to sub-anaesthetic oral ketamine treatment of PTSD to identify key molecular markers in building a predictive profile in determining longer term treatment outcomes. This study highlights the utility of integrating gene expression data with clinical outcomes to elucidate a molecular profile receptive to ketamine’s sustained therapeutic effects.

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Longitudinal Gene Expression Changes in PTSD Following Sub-Anaesthetic Oral Ketamine Administration

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Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression

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2018-10-17 | PXD002271 | Pride

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