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The effects of ATP and CD39 inhibition in monocyte-derived dendritic cells.

ABSTRACT: Extracellular ATP (eATP) is a damage associated molecular pattern (DAMP) that may be released by cancer cells as a result of chemotherapy-induced immunogenic cell death (ICD). We have demonstrated that preserving extracellular ATP (eATP) by inhibiting the extracellular ATPase CD39 boosts anti-tumor immunity in various models. We recently reported the development of AB598, a very specific and potent therapeutic antibody that inhibits CD39 enzymatic activity. We demonstrated using a cancer cell-moDC co-culture system that chemotherapy-induced ATP release with AB598 inhibition is sufficient to activate moDCs to a greater antigen presenting cell (APC) phenotype. Using this co-culture system, we generated and tested an ATP signature that shows promising utility in tumor biopsies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE287531 | GEO | 2026/02/02

REPOSITORIES: GEO

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