Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptome accessment of human aortic smooth muscle cell and rat aortic smooth muscle cell [HASMC_RASMC_RNASeq]

ABSTRACT: We report the transcriptome within human aortic smooth muscle cell and rat aortic smooth muscle cell. Some of the cells were treated with cholesterol.

ORGANISM(S): Rattus norvegicus Homo sapiens

PROVIDER: GSE287684 | GEO | 2025/05/29

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptome accessment of human aortic smooth muscle cell and rat aortic smooth muscle cell [HASMC_RASMC_RNASeq]

Project description:Transcriptome accessment of human aortic smooth muscle cell and rat aortic smooth muscle cell [HASMC_RASMC_RNASeq]

| PRJNA1214245 | ENA

Effect of IL-1b treatment on cultured rat aortic smooth muscle cells

Project description:IL-1 plays an important role in atherosclerosis, and alters expression of a number of genes involved in atherosclerotic plaque development and progression. Smooth muscle cells play important roles in atherosclerotic plaque formation and stability, so this study was undertaken to determine the global effects of IL-1b on gene expression in smooth muscle cells in vitro. Cultured rat aortic smooth muscle cells were treated with IL-1b (2.5 ng/mL) or vehicle (0.1% BSA) for 24 hours prior to harvest.

2012-12-31 | E-GEOD-21403 | biostudies-arrayexpress

Smooth muscle cell reprogramming in aortic aneurysms [RNA-Seq]

Project description:Smooth muscle cell TGFβ signaling is one of the primary drivers of smooth muscle cell maturation. Inhibition of smooth muscle cell TGFβ signaling in hyperlipidemic mice induces vessel wall inflammation and vessel wall dilation/dissection and leads aortic aneurysm. We performed bulk RNAseq method to examine smooth muscle cell gene expression profile using fresh human tissues from normal aortic media smooth muscle cells and aneurysm aortic media smooth muscle cells.

2020-03-01 | GSE140947 | GEO

Cholesterol and TNF-induced transcriptomic changes in Mus musculus aortic smooth muscle cells

Project description:To map gene regulation downstream of cholesterol overload and NF-kappaB signaling in smooth muscle cells (SMCs), we cultured primary aortic SMCs from wildtype mice with cyclodextrin-complexed cholesterol or the prototypical NF-kappaB activator, tumor necrosis factor (TNF), or both.

2023-05-29 | E-MTAB-12069 | biostudies-arrayexpress

Smooth muscle cell reprogramming in aortic aneurysms [scRNA-Seq]

Project description:Smooth muscle cell TGFβ signaling is one of the primary drivers of smooth muscle cell maturation. Inhibition of smooth muscle cell TGFβ signaling in hyperlipidemic mice induces vessel wall inflammation and vessel wall dilation/dissection and leads aortic aneurysm. We performed scRNAseq method to examine smooth muscle cell gene expression profile using Apoe and SMC specific TGFbR2 KO in Apoe background mice.

2020-03-01 | GSE141031 | GEO

Smooth muscle cell reprogramming in aortic aneurysms

Project description:Smooth muscle cell reprogramming in aortic aneurysms

| PRJNA591801 | ENA

Smooth muscle cell-specific Klf4 deletion in Marfan syndrome aortic root aneurysm

Project description:Aortic smooth muscle cell (SMC) phenotype modulation is a central feature of cell-mediated pathology in Marfan syndrome aortic aneurysm and Klf4 is proposed to contribute to this process. We generated mice with smooth muscle cell-specific Klf4 deletion using an Myh11-creERT2 transgene, induced deletion at 8 weeks and performed single cell RNA sequencing at 24 weeks on whole aortic root tissues.

2022-08-23 | GSE206227 | GEO

Nuclear Factor-kappa B inhibition in mouse aortic smooth muscle cells stimulated by cholesterol overload or tumor necrosis factor

Project description:To test whether cholesterol overload in smooth muscle cells (SMCs) drives NF-kappaB signaling and to map target genes controlled by NF-kappaB signaling in SMCs, we cultured primary aortic SMCs from wildtype mice in the presence of cyclodextrin-complexed cholesterol or the prototypical NF-kappaB activator tumor necrosis factor (TNF) with or without blocking canonical NF-kappaB signaling by knockdown of inhibitor of kappaB kinase beta (Ikbkb).

2023-12-07 | E-MTAB-13416 | biostudies-arrayexpress

scRNA-seq of lineage traced mouse aortic smooth muscle cells with cell Hashing

Project description:scRNA-seq of lineage traced mouse aortic smooth muscle cells with cell Hashing

2024-10-28 | GSE256361 | GEO

Transcription profiling of rat thrombin-stimulated vascular smooth muscle cells

Project description:The strength and duration of extracellular signal-regulated kinases 1/2 (ERK1/2) phosphorylation can define the phenotypic outcome of cells. Stimualtion of the proteinase-activated receptor (Par) triggers a Gi-dependent long-lasting transactivation of the epidermal growth factor receptor and subsequent ERK1/2 phosphorylation. To understand the mechnaisms underlying this signaling cascade, microarray analysis was performed in vascular smooth muscle cells. Experiment Overall Design: Par receptors on neonatal rat aortic smooth muscle cells were stimulated with thrombin or TRAP in presence or abscence of Gi-uncoupling pertussis toxin.

2009-05-02 | E-GEOD-15841 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data