Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Co-Conservation of Synaptic Gene Expression and Circuitry in Collicular Neurons

ABSTRACT: we compared the molecular and cellular organization of superior colliculus in mice, tree shrews, and humans. Our findings reveal that the SC has evolved by conserving neuron subtypes, synaptic genes, and circuitry, while diversifying ciliary gene expression and an inhibitory neuron subtype

ORGANISM(S): Mus musculus Tupaia belangeri

PROVIDER: GSE287986 | GEO | 2025/07/03

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Co-Conservation of Synaptic Gene Expression and Circuitry in Collicular Neurons.

Project description:The superior colliculus (SC), a midbrain sensorimotor hub, is anatomically and functionally similar across vertebrates, but how its cell types have evolved is unclear. Using single-nucleus transcriptomics, we compared the SC's molecular and cellular organization in mice, tree shrews, and humans. Despite over 96 million years of evolutionary divergence, we identified ~30 consensus neuronal subtypes, including Cbln2+ neurons that form the SC-pulvinar circuit in mice and tree shrews. Synapse-related genes were among the most conserved, unlike neocortex, suggesting co-conservation of synaptic genes and circuitry. In contrast, cilia-related genes diverged significantly across species, highlighting the potential importance of the neuronal primary cilium in SC evolution. Additionally, we identified a novel inhibitory SC neuron in tree shrews and humans but not mice. Our findings reveal that the SC has evolved by conserving neuron subtypes, synaptic genes, and circuitry, while diversifying ciliary gene expression and an inhibitory neuron subtype.

| S-EPMC11785205 | biostudies-literature

Project description:Tree shrews SNP

| PRJNA526583 | ENA

Project description:Tree shrews SNP

| PRJNA526585 | ENA

Project description:Tree shrews sequence

| PRJNA526600 | ENA

Transcriptome sequencing of Chinese tree shrew, Tupaia belangeri chinensis

Project description:Deep sequencing of mRNA from Chinese tree shrew; Chinese tree shrew (Tupaia belangeri chinensis) is placed in Order Scandentia and embraces many unique features for a good experimental animal model. Currently, there are many attempts to employ tree shrew to establish model for a variety of human disorders such as social stress, myopia, HCV and HBV infection, and hepatocellular carcinoma .We present here a publicly available annotated genome sequence for Chinese tree shrew. Phylogenomic analysis of tree shrew and other mammalians highly supported its close affinity to primates. Characterization of key factors and signaling pathways of the nervous and immune systems in tree shrews showed that this animal had common and unique features, and had essential genetic basis for being a promising model for biomedical researches. Analysis of ploy(A)+ RNA of different specimens:kidney, pancreas, heart, liver, brain, testis and ovary form Chinese tree shrew

2013-01-14 | E-GEOD-39150 | biostudies-arrayexpress

Transcriptome sequencing of Chinese tree shrew, Tupaia belangeri chinensis

2013-01-14 | GSE39150 | GEO

Gene expression profile at single cell level from the whole brain of two tree shrew fetus

Project description:Although continual expansion of the brain during primate evolution accounts for our enhanced cognitive capabilities, the drivers of brain evolution have scarcely been explored. Tree shrews are closely related to primates that comparing their brains to primate brains at the single-cell level will provide new insights into the evolution of the primate brain.

2023-07-15 | GSE233757 | GEO

Project description:tree shrews data 1

| PRJNA526599 | ENA

RNA-seq of choroid and retina in tree shrews with choroidal neovascularization

Project description:In order elucidate the key signaling pathways in choroidal neovascularization, we induced choroidal angiogenesis by laser photocoagulation in 12 tree shrews and obtained mRNA profiles of their choroids and retinas by high-throughput transcriptome sequencing. Gene ontology(GO) and kyoto encyclopedia of genes and genomes(KEGG) enrichment analysis, hierarchical cluster analysis, weighted gene co-expression network analysis, protein-protein interaction (PPI) network analysis, and reverse transcription quantitative PCR (RT-qPCR) were performed.

2021-03-21 | E-MTAB-10198 | biostudies-arrayexpress

The Novel miR_146-Tfdp2 Axis Antagonizes METH-Induced Apoptosis and Cell Cycle Abnormalities in Tree Shrew Primary Neurons

Project description:This project focuses on the neurotoxic effects of methamphetamine (METH) abuse and its impact on the central nervous system. Methamphetamine is a highly addictive synthetic drug that can cause severe cognitive and behavioral changes, as well as neurodegenerative diseases. We conducted transcriptome sequencing on METH-treated primary neurons from tree shrews to investigate the underlying mechanisms of METH-induced neuronal damage.

2024-10-31 | GSE278309 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data