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Thymic iNKT cells in Prkd2/3 mice (scRNA/TCR-seq, scATAC-seq)

ABSTRACT: We have conducted single cell-RNA, -TCR, -ATAC sequencing (10x Genomics) to investigate a difference of gene expression, TCR repertoir and chromatin accesibility of thymic iNKT cells from wild-type and CD4-Cre-mediated T cell-specific Prkd2/3 doubly deficirnt (Prkd2/3ΔCD4) mice. Results demonstrate that Prkd2/3 are required for iNKT cell development and formaion of proper iNKT cell subtypes.

ORGANISM(S): Mus musculus

PROVIDER: GSE288015 | GEO | 2025/09/08

REPOSITORIES: GEO

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