SnRNAseq of diffuse leptomeningeal glioneuronal tumors

ABSTRACT: As part of a larger study on disseminated pediatric low-grade gliomas, we performed scRNAseq on two diffuse leptomeningeal glioneuronal tumors (DLGNT), one of which remained low-grade, and the other of which underwent high-grade transformation. Using this data, we compared the cellular pathway activation of each tumor, identifying a subpopulation of highly proliferative tumor cells in the transformed sample, which had elevated MAPK pathway activity and depressed p53 pathway activity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE288107 | GEO | 2026/03/18

REPOSITORIES: GEO