Neuronal GDF-15 delivery alters peripheral CD4+ T cell phenotype

ABSTRACT: In this study we investigated the immunomodulatory properties of GDF-15 in the context of neuroinflammation. We exploited neuronal gene therapy to overexpress GDF-15 within the central nervous system, which protected mice from developing any clinical signs of neuroinflammation in the experimental autoimmune encephalitis (EAE) model. We discovered that GDF-15 delivery modulated the peripheral T cell response and prevented immune cells from transmigrating into the central nervous system.

ORGANISM(S): Mus musculus

PROVIDER: GSE288193 | GEO | 2025/11/20

REPOSITORIES: GEO