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Co-targeting of epigenetic regulators and BCL-XL improves efficacy of immune checkpoint blockade therapy in solid tumors

ABSTRACT: We have used a single-cell sequencing approach to study the changes induced in the immune cells present in the tumor microenvironment of Lewis lung cancer (LLC) mouse tumors treated with a novel therapeutic strategy based on a dual inhibitor of G9a and DNMTs (CM272), a Bcl-XL inhibitor (A1331852) and anti-PD-1 (RMP1-14).

ORGANISM(S): Mus musculus

PROVIDER: GSE288231 | GEO | 2025/05/30

REPOSITORIES: GEO

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MicroRNA expression data from Bcl-xL silenced A549 lung adenocarcinoma cells

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