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Endogenous retroviruses promote aberrant T cell differentiation in systemic lupus erythematosus via the RIG-I pathway [whole transcriptomics]

ABSTRACT: The dysregulated differentiation of T lymphocytes play an important role in systemic lupus erythematosus (SLE). However, the underlying mechanism remains unclear. Here, we screened and identified many overexpressed HERVs in CD4+ T cells from SLE patients by whole transcriptome resequencing and found that some HERVs formed dsRNAs to induce the activation of the RIG-I signaling pathway. And our findings reveal the roles and mechanism of HERVs and RIG-I in regulating the aberrant differentiation of T cells in SLE patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE288271 | GEO | 2025/11/18

REPOSITORIES: GEO

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Endogenous retroviruses promote aberrant T cell differentiation in systemic lupus erythematosus via the RIG-I pathway [SLE]

Project description:The dysregulated differentiation of T lymphocytes play an important role in systemic lupus erythematosus (SLE). However, the underlying mechanism remains unclear. Here, we screened and identified many overexpressed HERVs in CD4+ T cells from SLE patients by RNA-seq and found that some HERVs formed dsRNAs to induce the activation of the RIG-I signaling pathway. And our findings reveal the roles and mechanism of HERVs and RIG-I in regulating the aberrant differentiation of T cells in SLE patients.

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