Angiotensin Converting Enzyme (ACE) expression in microglia reduces amyloid β deposition and neurodegeneration by increasing SYK signaling and endolysosomal trafficking

ABSTRACT: Angiotensin Converting Enzyme (ACE) has been studied for its role in the regulation of myeloid cell bactericidal and antitumor activity. Here, we generated a mouse model with Tamoxifen-dependent ACE expression and Cx3CR1-Cre control. These mice were crossed to 5xFAD and 9 month forebrains were harvested and FFPE processed to assess the ACE-dependent changes in amyloid-reactive microglia.

ORGANISM(S): Mus musculus

PROVIDER: GSE288280 | GEO | 2025/03/24

REPOSITORIES: GEO