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Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE288339 | GEO | 2026/02/16

REPOSITORIES: GEO

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Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [ChIP-exo]

Project description:Structural loops are known to collapse in the absence of cohesin, whereas regulatory loops largely persist with only minor transcriptional changes, leaving unresolved questions about cohesin’s role in establishing regulatory interactions during cell state transitions. To investigate this, we degraded RAD21, a core cohesin subunit, in mouse embryonic stem cells (ESCs) transitioning from mitosis to G1 under self-renewal or differentiation conditions. We performed ChIP-exo for H3K4me3 to map marked regions and for CTCF and RAD21 to map binding regions in ESCs.

2026-02-16 | GSE288299 | GEO

Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [4C-seq]

Project description:Structural loops are known to collapse in the absence of cohesin, whereas regulatory loops largely persist with only minor transcriptional changes, leaving unresolved questions about cohesin’s role in establishing regulatory interactions during cell state transitions. To investigate this, we degraded RAD21, a core cohesin subunit, in mouse embryonic stem cells (ESCs) transitioning from mitosis to G1 under self-renewal or differentiation conditions. We performed high-resolution in situ 4C-seq around the promoters of cohesin-sensitive genes (Klf4, Tbx3, Myc, and Fosl2) in ESCs and EpiLCs.

2026-02-16 | GSE288298 | GEO

Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [Micro-C]

Project description:Structural loops are known to collapse in the absence of cohesin, whereas regulatory loops largely persist with only minor transcriptional changes, leaving unresolved questions about cohesin’s role in establishing regulatory interactions during cell state transitions. To investigate this, we degraded RAD21, a core cohesin subunit, in mouse embryonic stem cells (ESCs) transitioning from mitosis to G1 under self-renewal or differentiation conditions. We performed Micro-C to map changes in 3D chromatin architecture in ESCs upon RAD21 depletion and p300/CBP inhibition.

2026-02-16 | GSE288301 | GEO

Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [RNA-seq]

Project description:Structural loops are known to collapse in the absence of cohesin, whereas regulatory loops largely persist with only minor transcriptional changes, leaving unresolved questions about cohesin’s role in establishing regulatory interactions during cell state transitions. To investigate this, we degraded RAD21, a core cohesin subunit, in mouse embryonic stem cells (ESCs) transitioning from mitosis to G1 under self-renewal or differentiation conditions. We performed RNA-seq to profile gene expression in ESCs and EpiLCs.

2026-02-16 | GSE288300 | GEO

Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [ChIP-seq]

Project description:Structural loops are known to collapse in the absence of cohesin, whereas regulatory loops largely persist with only minor transcriptional changes, leaving unresolved questions about cohesin’s role in establishing regulatory interactions during cell state transitions. To investigate this, we degraded RAD21, a core cohesin subunit, in mouse embryonic stem cells (ESCs) under self-renewal or differentiation conditions. We performed ChIP-seq for H3K4me3, H3K27ac, RAD21 and HA.

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Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion

Project description:Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion

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Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [ChIP-exo]

Project description:Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [ChIP-exo]

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Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [4C-seq]

Project description:Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [4C-seq]

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Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [RNA-seq]

Project description:Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [RNA-seq]

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Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [Micro-C]

Project description:Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion [Micro-C]

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