Effect of depletion of FAT4 on gene expression in A673 Ewing sarcoma cells

ABSTRACT: Ewing sarcoma is a cancer of bone and soft tissue in children characterized by a chromosomal translocation that fuses EWS and an ETS family transcription factor, most commonly FLI1. EWS-FLI1 is the driver of this cancer. Using secretome proteomics and molecular cell biology, we found that FAT4, an atypical cadherin inhibiting Hippo signaling, is a transcriptional target of EWS-FLI and is a dependency in Ewing sarcoma. We used RNA-sequencing to determine the gene expression changes caused by FAT4 silencing in Ewing sarcoma cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE288384 | GEO | 2026/04/01

REPOSITORIES: GEO